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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T3041 | ALK inhibitor 2 | FAK , ALK | |
ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase. | |||
T10285 | ALK inhibitor 1 | FAK , IGF-1R , ALK | |
ALK inhibitor 1 is a selective ALK kinase inhibitor. | |||
T9576 | AMP-945 | FAK | |
AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor. | |||
T9973 | FAK-IN-7 | FAK | |
FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor. | |||
T2001 | PF-573228 | PF 573228 | Apoptosis , FAK |
PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM. | |||
T2314 | PF-431396 | FAK , PYK2 | |
PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM). | |||
T6997 | SU6656 | FAK , Akt , Src | |
SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively. | |||
T2281 | GSK2256098 | GSK 2256098,GSK-2256098,GTPL7939 | Apoptosis , FAK |
GSK2256098 (GTPL7939) is a small molecule FAK kinase inhibitor. | |||
T5480 | BI-4464 | FAK , Ligands for Target Protein for PROTAC | |
BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC | |||
T2465 | PF-562271 | PF562271,PF 562271 | FAK , PYK2 , CDK |
PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM). | |||
T1996 | Defactinib | PF-04554878,VS-6063 | FAK |
Defactinib (VS-6063) is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. | |||
T2655 | CEP-37440 | CEP37440 | FAK , ALK |
CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK). | |||
T6177 | PF-562271 besylate | PF-00562271 Besylate | FAK , PYK2 , CDK |
PF-562271 besylate (PF-00562271 Besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, exc... | |||
T24730 | Roslin 2 bromide | Roslin-2,Benzylhexamethylenetetramine bromide,Roslin2 | FAK , p53 |
Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5. Roslin 2 bromide exhibits anticancer effects. | |||
T0263 | Chloropyramine hydrochloride | Nilfan,Alergosan,Halopyramine hydrochloride | FAK , VEGFR , Histamine Receptor |
Chloropyramine hydrochloride (Alergosan) is a histamine receptor H1 antagonist. | |||
T1918 | NVP-TAE 226 | TAE226 | Apoptosis , FAK , c-Met/HGFR , PYK2 , IGF-1R |
NVP-TAE 226 (TAE226) is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, c-Met, and ALK. | |||
T21768 | PF-562271 hydrochloride | PF-562271 HCl | FAK , PYK2 , CDK |
PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other pr... | |||
T2609 | Masitinib | AB1010 | Apoptosis , FAK , c-Fms , FGFR , Bcr-Abl , PDGFR , Src , c-Kit , Hck |
Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has been distributed under the commercial name Masivet... | |||
T1950 | PND-1186 | PND1186,PND 1186,VS-4718,SR-2516 | Apoptosis , FAK |
PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM). | |||
T7119 | Y15 | 1,2,4,5-Benzenetetramine tetrahydrochlor,FAK Inhibitor 14 | FAK |
Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth. | |||
T67843 | GSK215 | FAK | |
GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader (pDC50= 8.4). GSK215 is designed by the FAK inhibitor VS-4718 and a binder for the VHL E3 ligase. GSK215 can induce rapid and prolonged FAK deg... | |||
T23539 | Y 11 | Others | |
focal adhesion kinase (FAK) inhibitor | |||
T22397 | PF-4618433 | Others | |
PF-4618433 is a dual inhibitor of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). | |||
T28277 | OXA-11 | OXA 11 | |
OXA-11 is a potent inhibitor of focal adhesion kinase (FAK) with anti-tumor activity. | |||
T11260 | FAK inhibitor 2 | FAK | |
FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM . | |||
T70724 | GSK-2256098 HCl | ||
GSK-2256098 HCl is a focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. | |||
T35075 | VSWRAPTA | ||
VSWRAPTA is a promoter of neuronal branching via transcellular activation of the focal adhesion kinase (FAK) and the ERK1/2 signaling pathway in vitro. | |||
T68740 | NVP-TAC544 | ||
NVP-TAC544 is a novel focal adhesion kinase (FAK) inhibitor, potently blocking kinase activity of FAK along with Aurora A, activated Cdc42-associated kinase 1 (ACK1), Met, insulin receptor (IR), TrkA, and IGF-1R. | |||
T13840 | PROTAC FAK degrader 1 | Others | |
PROTAC FAK degrader 1 is a selective and potent degrader of focal adhesion kinase (Fak) (IC50 of 6.5 nM). | |||
T70352 | PH11 | ||
PH11 is a novel Focal Adhesion Kinase (FAK) inhibitor. PH11 restores TRAIL apoptotic pathway in PANC-1 cells through down-regulation of c-FLIP via inhibition of FAK and the phosphatidylinositol-3 kinase (PI3K)/AKT path... | |||
T83680 | Azurin (50-77) (P. aeruginosa) TFA | Azurin p28,p28 | |
Azurin (50-77) is a peptide fragment derived from the copper-containing bacterial protein azurin, present in P. aeruginosa. It exhibits properties that regulate the cell cycle, inhibit cancer proliferation, and manage an... |
カタログ番号 | 製品名 | 別名 | ターゲット |
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TN1433 | Batatasin III | FAK , Others , Akt | |
Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer activities. Batatasin III has a long-term inhibitory effect on whole-... | |||
T5S0761 | Nitidine chloride | Apoptosis , ERK , FAK , p38 MAPK , NF-κB , Topoisomerase , STAT , Parasite | |
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and id... | |||
T3122 | Fangchinoline | Tetrandrine B,(+)-Limacine,Hanfangichin B,(+)-Fangchinoline | Apoptosis , FAK , HIV Protease , Autophagy |
Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore. |
カタログ番号 | 製品名 | Species | Expression System |
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TMPJ-00678 | STX6 Protein, Human, Recombinant | Human | E. coli |
Syntaxin-6 (STX6) is a single-pass type IV membrane protein, which belongs to the Syntaxin family. STX6 is mainly localized in the plasma membrane. STX6 contains one t-SNARE coiled-coil homology domain and involved in in... | |||
TMPH-01539 | ILK Protein, Human, Recombinant (His) | Human | Baculovirus |
Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered ... | |||
TMPY-03060 | Parvin alpha/PARVA Protein, Human, Recombinant (GST) | Human | E. coli |
Actopaxin, also known as alpha-parvin, belongs to the parvin family. It is widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. Actopaxin contains 2 CH (calponin-homology) domains and probab... | |||
TMPY-02392 | Syndecan-4 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
SDC4 (Syndecan-4), also known as Syn4, is a transmembrane heparan sulfate proteoglycan that co-operates with integrins during cell-matrix interactions for the assembly of focal adhesions and actin stress fibers and in th... | |||
TMPY-05300 | Syndecan-4 Protein, Human, Recombinant (His) | Human | HEK293 |
SDC4 (Syndecan-4), also known as Syn4, is a transmembrane heparan sulfate proteoglycan that co-operates with integrins during cell-matrix interactions for the assembly of focal adhesions and actin stress fibers and in th... | |||
TMPY-03576 | Syndecan-4 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
SDC4 (Syndecan-4), also known as Syn4, is a transmembrane heparan sulfate proteoglycan that co-operates with integrins during cell-matrix interactions for the assembly of focal adhesions and actin stress fibers and in th... | |||
TMPY-02198 | ILKAP Protein, Human, Recombinant (His) | Human | HEK293 |
Integrin-linked kinase-associated serine/threonine phosphatase 2C, also known as ILKAP, is a cytoplasm protein that belongs to the PP2C family. ILKAP contains one PP2C-like domain. ILKAP is widely expressed. Highest leve... | |||
TMPY-04383 | CSK Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
The tyrosine kinase c-Src has been implicated as a modulator of cell proliferation, spreading, and migration. These functions are also regulated by Met. The structure of a large fragment of the c-Src kinase comprises the... | |||
TMPY-04444 | CSK Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus-Insect Cells |
The tyrosine kinase c-Src has been implicated as a modulator of cell proliferation, spreading, and migration. These functions are also regulated by Met. The structure of a large fragment of the c-Src kinase comprises the... | |||
TMPY-04760 | CSK Protein, Mouse, Recombinant | Mouse | Baculovirus-Insect Cells |
The tyrosine kinase c-Src has been implicated as a modulator of cell proliferation, spreading, and migration. These functions are also regulated by Met. The structure of a large fragment of the c-Src kinase comprises the... |